الرئيسية » أرشيف الوسم : chromic

أرشيف الوسم : chromic

Barbier-Wieland degradation

The stepwise degradation of a car­boxylic acid to the next lower homo­logue. First the ester is converted into a tertiary alcohol using a Grig­nard reagent (PhMgX) and acid (HX): RCH2COOCH3 → RCH2C(OH)Ph2 The secondary alcohol is then dehy­drated using ethanoic anhydride (CH3COOCOCH3) to give an alkene: RCH2C(OH)Ph2 → RCH=CPh2 The …

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